Drug combination therapy involves the use of two or more medications to treat a particular condition. This approach is commonly used in the treatment of various diseases, including cancer, HIV/AIDS, and tuberculosis, among others. Drug combination therapy can offer several benefits, such as enhanced efficacy, reduced toxicity, and prevention of drug resistance. By targeting multiple pathways or mechanisms of disease, combination therapy can improve treatment outcomes and reduce the likelihood of treatment failure. However, there are also challenges associated with drug combination therapy, including the potential for drug interactions, increased risk of side effects, and the complexity of managing multiple medications. Researchers continue to explore the optimal combinations of drugs and dosages to maximize the benefits of combination therapy while minimizing adverse effects.